The study did a side-by-side comparison of those with coeliac disease to "healthy control individuals" (i.e., those without Celiac Disease or Gluten Intolerance), and the findings were quite clearly in favor of encouraging B-Vitamin use among Celiac patients - especially B6 and Folate (oddly enough, this study did not result in a correlation between B12 consumption and a reduction in homocysteine levels that other studies have):
They found that patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003), folate (P < p =" 0.012)" p =" 0.035," p =" 0.007," style="font-weight: bold;">Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homo-cysteine levels.Well, we need to keep in mind here that the study was about homocysteine levels in patients with Celiac, and the effect of vitamin-dosing on those levels. And I forgot to mention that the reason that lower homocysteine levels are important (in general): above-normal homocysteine levels are correlated as strong risk factors for cardiovascular disease. Thus, in theory, lowering your homocysteine levels is a good thing if you want to avoid cardiovascular problems.
The study's findings about a lesser correlation between Vitamin B-12 and homocysteine levels goes against some other studies I have read about B-12 being effective for homocysteine lowering (in the normal population), but perhaps it is less of the direct-cause for high-homocysteine levels in Celiac patients particularly? I do not know, but I will still take my large doses of Vitamin-B12 regardless, as they make me feel better. (See my prior Gluten-Free Blog post on getting B12 to absorb well, without B12 shots, by taking sublingual B12 - i.e., under-the-tongue B12)
Now, for a final bit of science / techie conclusion quoted from the study-excerpt I read, here is the summary statement of why B-Vitamins / Folate is a good thing for us Gluten-Free folks:
The study demonstrates in agreement with earlier findings, that both the presence and the severity of coeliac disease were determinants of homocysteine levels. The regular use of B vitamin supplements was associated with higher serum vitamin B6, folate, and vitamin B12 and lower plasma homocysteine levels in patients with coeliac disease. Furthermore, B vitamin supplements seem to have a protective role against the effect of villous atrophy on homocysteine levels, irrespective to the genetic susceptibility status as manifested by carrying the C677T polymorphism of 5,10-methylenetetrahydrofolate reductase.I want my villi protected! :)
OK, so it is perhaps time to make sure you take some B-vitamins as part of your daily routine. As always though, consult with a doctor about large doses of vitamins, folate, etc... there really CAN be side-effects with some. Vitamin B-6 for example, in large doses, can lead to some types of neuropathy (i.e., numbness in hands/feet) and other nerve problems that you likely do not want. The only vitamin in this study that is nearly completely safe at extremely high doses (as a multiple of "RDA") is Vitamin B-12, but I will leave the dosing up to you and your doctor regardless.
Note: the excerpt I was reading was from here.